Prevalence of Sleep Apnea Syndrome in Patients With Type 1 Diabetes (APT1)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Diabetes Mellitus, Type 1

Treatments: Other: standard polysomnography

Study type: Interventional

Funder types: Other

Identifiers

NCT03506022

PI2017_843_0019

Details and patient eligibility

About

Obstructive sleep apnea (OSA) and Type 2 diabetes are two frequent diseases that occur in adult population. The prevalence of OSA is higher in people with Type 2 diabetes compared with the general population7 ; in addition, the OSA syndrome is almost assessed in obese type 2 diabetes. The relationship between OSA and Type 2 diabetes has been well characterized: the OSA can contribute to increased insulin resistance or glucose intolerance; and, diabetes may worsen sleep-disordered breathing because of autonomic neuropathy8,9. The main link between OSA and Type 2 diabetes is central obesity, which triggers glucose intolerance/insulin resistance and is also an independent risk factor for OSA. Type 1 diabetes is generally not related to obesity; however, sleep-disordered breathing in these patients was described in few reports early as 1985 by pioneers such as Guilleminault5 and the prevalence of OSA is estimated at range 10 to 40% in type 1 diabetes patients. Few studies had evaluated the prevalence of sleep disorders in particular the sleep apnea syndrome in patients with type 1 diabetes and even less their influence on the glycemic control.

This study will take place at the CHU of Amiens-Picardie during a one-night hospitalization. The investigators will study in 44 type 1 diabetes mellitus (IAH apnea hypopnea index ≥15) who underwent polysomnography and continuous glucose monitoring of blood glucose

Enrollment: 53 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients over 18 years
• with type 1 mellitus diabetes

Exclusion criteria

• Type-free diabetes (type 1 slow),
• Age <18 years
• A poor compliance with the follow-up (meetings unfulfilled without justification).
• All patients with known sleep disorders (OSA, narcolepsy, idiopathic hypersomnia).

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

53 participants in 1 patient group

patients with type 1 mellitus diabetes

Other group

Description:

All participants were admitted in sleep laboratory and screened for one night of 8 hours employing standard polysomnography (Brainnet System - Medatec) parameters

Treatment:

Other: standard polysomnography