Prevalence of Thyroid Dysfunction and Anti-thyroid Antibodies in Infertile Women

Cairo University (CU)

Status

Unknown

Conditions

Infertility, Female

Treatments

Diagnostic Test: Antibody assay

Diagnostic Test: Hormonal assay

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

The study population will be divided into three groups:

Group (A) consisting of 40 infertile women with either unexplained or anovulatory infertility with/without associated male factor of infertility,
Group (B) consisting of 40 infertile women with tubal (mechanical) factor of infertility with/without associated male factor of infertility, and
Group (C) consisting of 40 women with exclusive male factor of infertility and will be used as a control group.

. All women will be subjected to:
Informed consent
Full history taking, including age, duration of infertility and whether primary or secondary
General and pelvix examination
Trans-vaginal ultrasonography
Determination of hormonal profile (FSH, LH, Estradiol, Prolactin)
Determination of ovulatory status
Determination of of tubal patency
Determination of presence of male factor
Determination of TSH and antithyroid antibodies (antithyroglobulin and antithyroid peroxidase) blood levels

Full description

The study population will be divided into three groups:

Group (A) consisting of 40 infertile women with either unexplained or anovulatory infertility with/without associated male factor of infertility,
Group (B) consisting of 40 infertile women with tubal (mechanical) factor of infertility with/without associated male factor of infertility, and
Group (C) consisting of 40 women with exclusive male factor of infertility and will be used as a control group.

. All women will be subjected to:
Informed consent
Full history taking, including age, duration of infertility and whether primary or secondary
General and pelvix examination
Trans-vaginal ultrasonography
Determination of hormonal profile (FSH, LH, Estradiol, Prolactin)
Determination of ovulatory status (by previous documented history of induction of ovulation OR previous ultrasonography OR previous estimation midluteal serum progesterone, etc ...)
Determination of of tubal patency (by previous hysterosalpingiography or laparoscopy)
Determination of presence of male factor (by seminal fluid analysis)
Determination of TSH and antithyroid antibodies (antithyroglobulin and antithyroid peroxidase) blood levels

Enrollment

120 estimated patients

Sex

Female

Ages

20 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

- Age: 18 - 38 years
Infertile women whether due to functional, anatomical, male factors OR unexplained OR combined factors

Exclusion criteria

- Age: below 18 and above 38 years
Patients with autoimmune diseases (such as lupus and rheumatoid arthritis)
Acute illness that require hospitalization
Patients on the following medications: steroids, dopamine, iodine, amiodarone, lithium, donperidone, thyroid hormone, and phenytoin.
Patients who work at night.