PRevalence Of Transient Global Amnesia in Obstructive Sleep Apnea Syndrome (PROTOS)

University Hospital, Strasbourg, France

Status: Enrolling

Conditions: Transient Global Amnesia

Study type: Observational

Funder types: Other

Identifiers

NCT06903026

8781

Details and patient eligibility

About

Amnesic stroke is an amnestic syndrome lasting less than 24 hours characterized by the occurrence of anterograde amnesia often associated with retrograde amnesia, the pathophysiology of which is still poorly understood at present. A recent study on a small sample size (N=29) highlighted an association between obstructive sleep apnea syndrome and amnesic stroke. Our study seeks to confirm or refute these results on a larger cohort (N=200-250). A better understanding of the pathophysiological processes involved would open up new therapeutic avenues.

Enrollment: 250 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients seen for consultation in the Neuropsychology Department of Strasbourg University Hospital between March 1, 2015 and December 31, 2021 following an episode of amnestic stroke meeting the Hodges and Warlow criteria:
• The stroke must have been documented and reported by a competent witness present during the stroke.
• Anterograde amnesia during the stroke.
• Absence of vigilance, personality, and cognitive disorders other than memory disorders (aphasia, apraxia, etc.).
• Absence of focal neurological symptoms during the episode and its aftermath.
• Absence of epileptic manifestations.
• Resolution of the episode in less than 24 hours.
• Exclusion of patients with a history of recent head trauma or active epilepsy (undergoing regular treatment or having experienced a seizure in the last 2 years).
• Subjects who have not expressed opposition to the reuse of their data for scientific research purposes.

Exclusion criteria

• Patients who have expressed opposition to the retrospective reuse of their data for scientific research purposes.
• Patients with active epilepsy
• Patients with recent head trauma
• Patients with an MMS < or equal to 25
• Subject under guardianship or curatorship
• Subject under judicial protection