Prevalence of Wild Type Transthyretin Cardiac Amyloidosis in Patients Operated for Idiopathic Carpal Tunnel Syndrome (CACTuS)

Aarhus University Hospital Skejby

Status: Completed

Conditions: Amyloidosis Cardiac; Carpal Tunnel Syndrome

Treatments: Diagnostic Test: DPD Scintigraphy

Study type: Interventional

Funder types: Other

Identifiers

NCT03996382

1-10-72-330-18

Details and patient eligibility

About

Wild-type transthyretin cardiac amyloidosis is an underdiagnosed depository disease in which fibril monomers of misfolded amyloid protein accumulates in various tissues, including the heart, and cause tissue dysfunction.

Before onset of cardiac symptoms, many patients will have undergone surgery for idiopathic carpal tunnel syndrome since the protein also deposits in the transversal carpal ligament of the hand.

This study investigates patients previously operated for idiopathic carpal tunnel syndrome to determine if they display signs and symptoms of cardiac amyloidosis.

Enrollment: 120 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients above sixty years of age previously operated for idiopathic carpal tunnel syndrome within the Region of Central Denmark (Region Midtjylland) the last five years.
• Informed written and verbal consent

Exclusion criteria

• Operation by different indication such as

  • Fracture
  • Ganglion
  • Tumors
  • Osteophytes
  • Rheumatoid Arthritis
  • Persistent medial artery
  • Metabolic causes

• Alcoholism

• Hyperthyroidism

• Myxedema

  • Hereditary Cardiac Amyloidosis
  • Known WT ATTR
  • AL Amyloidosis
  • Myelomatosis
  • MGUS and Morbus Waldenström

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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120 participants in 1 patient group

Suspicion of cardiac amyloidosis

Other group

Description:

Patients who display signs of cardiac amyloidosis will be referred for further diagnosis.

Treatment:

Diagnostic Test: DPD Scintigraphy