Preventing Depression in People With Epilepsy: an Extension of Project UPLIFT

Emory University

Status: Completed

Conditions: Depressive Symptoms; Epilepsy; Seizure Disorder; Depression

Treatments: Behavioral: Project UPLIFT

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01941706

09042433 (Other Identifier)

5RC1MD004563-02 (U.S. NIH Grant/Contract)

IRB00026786

Details and patient eligibility

About

Project UPLIFT, a home-based treatment for depression in people with epilepsy, was designed to be delivered to groups by telephone or Web. The Project UPLIFT intervention materials were demonstrated to be effective in treating depression among people with epilepsy in Georgia. This project will assess whether the materials are also effective for preventing depression among people with epilepsy, and will extend the project beyond Georgia to Michigan, Texas, and Washington.

Full description

The study is a pilot test of Project UPLIFT for depression prevention during which the acceptability and estimates of effectiveness of the intervention, presented in the Web and telephone modes, are assessed.

Enrollment: 130 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of epilepsy
• at least three months post initial diagnosis of epilepsy and either on medication or permission of the physician
• symptoms of depression, but absence of moderate-to-severe depression, (8 < CES-D < 27)
• 21 years of age and older
• English speaking
• had access to a telephone
• mentally stable, as determined by a score of > 26 on the Telephone Mini-Mental Status Exam (T-MMSE)
• willing to participate
• willing to complete assessments three times

Exclusion criteria

• no diagnosis of epilepsy
• less than 3 months since diagnosis of epilepsy
• no depressive symptom (CES-D <8)
• severe depression (CES-D > 27)
• suicidal ideation
• previous participation in Project UPLIFT

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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130 participants in 2 patient groups

Project UPLIFT (Treatment)

Experimental group

Description:

Participants randomly assigned to the Treatment group receive the UPLIFT Intervention immediately after completing the Baseline Assessment. Participants can chose to participate in the Web- or phone-delivery of UPLIFT.

Treatment:

Behavioral: Project UPLIFT

Project UPLIFT (TAU Waitlist Control)

Experimental group

Description:

Participants randomly assigned to the Treatment-as Usual (TAU) Waitlist Control group will also receive the UPLIFT intervention. However, TAU Waitlist Control participants will begin the Intervention 8 weeks after completing the Baseline Assessment. During the initial 8 weeks, participants in this group will continue whatever treatment they are currently undergoing to prevent or treat mild depressive symptoms. Participants can chose to participate in the Web- or phone-delivery of UPLIFT.

Treatment:

Behavioral: Project UPLIFT