Preventing Depression in the Children of Depressed African American Mothers

Children's Hospital of Philadelphia (CHOP)

Status and phase: Completed; Phase 1

Conditions: Depression

Treatments: Behavioral: Psychoeducation; Behavioral: Prevention Intervention Project

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00904917

DSIR 8K-RTCT

IRB NO: 2004-10-4041 (Other Identifier)

K01MH068619 (U.S. NIH Grant/Contract)

2004-10-4041

Details and patient eligibility

About

The purpose of the study is to adapt and test the Preventive Intervention Project for urban African American mothers with depression and their children.

Full description

Abstract

Background: There is limited representation of ethnic minorities in preventive interventions for the generational impact of maternal depression.

Methods: The Preventive Intervention Project (PIP) was adapted to be culturally and contextually relevant for urban African American mothers with depression and their children. A pilot clinical trial (PIP vs. lecture) was conducted.

Enrollment: 34 patients

Sex: All

Ages: 8 to 14 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Mothers:

Inclusion Criteria:

• African American
• Primary current or past-year diagnostic and statistical manual (DSM-IV) diagnosis of Major Depressive Disorder, Dysthymic Disorder, or Depressive Disorder not otherwise specified
• Parent or guardian and primary caregiver of a child 8 to 14 years old
• Resided at least part time for the past year with the targeted child
• May be receiving psychopharmacological treatment, psychosocial services, or both

Exclusion Criteria:

• Current or lifetime history of schizophrenia
• Current or lifetime history of bipolar disorder
• Current or past-year diagnosis of alcohol or drug dependency
• Serious medical disorder, neurological disorder, condition, or chronic pain that prevents participation
• Documented mental retardation
• Current suicide risk sufficient to preclude outpatient treatment

Children:

Inclusion Criteria:

• Have an African American mother with a depressive disorder
• 8 to 14 years old
• Reside at least part time with mother

Exclusion Criteria:

• Currently in treatment for depression or an anxiety disorder
• Presence of a medical or psychiatric condition contraindicating study intervention, such as mental retardation, suicidality, or pervasive developmental disorder

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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34 participants in 2 patient groups

Adapted PIP

Experimental group

Description:

Participants (both mother and children) participated in an adapted cognitive family prevention program for the families of children with a depressed African American mother. The intervention was the Prevention Intervention Project.

Treatment:

Behavioral: Prevention Intervention Project

Lecture

Active Comparator group

Description:

Mothers received psychoeducation about depression. The intervention was psychoeducation.

Treatment:

Behavioral: Psychoeducation