Preventing Myocardial Ischemia by Preconditioning in Elective Operation for Abdominal Aortic Aneurysm

Aarhus University Hospital

Status and phase: Unknown; Phase 1

Conditions: Aortic Aneurysm

Treatments: Procedure: Normal surgery, with sham intervention without inflating arm cuff; Procedure: preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT01523262

M-20100012

Details and patient eligibility

About

Primary To investigate whether peripheral predonditioning induced by brief, intermittent constriction of blood supply to an arm can reduce the incidence of perioperative myocardial ischemia in patients operated electively for infrarenal aortic aneurysm.

Secondary To investigate the impact of peripheral preconditioning on perioperative inflammatory response.

To investigate whether peripheral preconditoning can protect against perioperative myocardial infarction and reduced cardiac pump function.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All patients older than 18 years, hospitalized for elective surgery of abdominal aortic aneurysm

Exclusion criteria

• Lack of informed consent.
• Hemiparetic patient.
• Pregnancy or nursing patient.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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200 participants in 2 patient groups, including a placebo group

Preconditioning and normal treatment

Active Comparator group

Treatment:

Procedure: preconditioning

normal treatment

Placebo Comparator group

Description:

Standard treatment

Treatment:

Procedure: Normal surgery, with sham intervention without inflating arm cuff