Prevention of Alcohol Intolerance

Johns Hopkins University

Status and phase: Completed; Phase 2

Conditions: Alcohol Sensitivity

Treatments: Drug: Placebo; Drug: Broccoli Sprout Extract

Study type: Interventional

Funder types: Other

Identifiers

NCT01845220

NA_00081276

Details and patient eligibility

About

This study is designed to determine whether Asians who are especially sensitive to alcohol exposure can be protected by boosting their activities of an alcohol disposing enzyme. This will be accomplished by administering broccoli sprouts that are rich in an agent that increases protective enzyme activity. The test system involves applying alcohol patches to the skin and measuring skin redness.

Enrollment: 30 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-70 years old,
• sensitive to alcohol on the skin, Japanese

Exclusion criteria

• recent skin abnormalities /tanning

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

Broccoli Sprout Extract

Active Comparator group

Description:

Each subject will act as his/her own control and receive both treatment and placebo on adjacent skin regions.

Treatment:

Drug: Broccoli Sprout Extract

Placebo

Placebo Comparator group

Description:

Each subject will act as his/her own control and receive both treatment and placebo on adjacent skin regions.

Treatment:

Drug: Placebo