Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting in Patients With Obstructive Sleep Apnea (PAFOS)

Rodrigo Pinto Pedrosa

Status: Completed

Conditions: Atrial Fibrillation; Coronary Artery Bypass Grafting; Obstructive Sleep Apnea

Treatments: Device: CPAP

Study type: Interventional

Funder types: Other

Identifiers

NCT02737215

PAFOS01

Details and patient eligibility

About

Background. Atrial fibrillation is one of the most common complications in the postoperative period of coronary artery bypass grafting (CABG) surgery and usually associated with increased length of hospital stay and higher hospital costs. Among the main mechanisms involved, excessive sympathetic activation, oxidative stress and inflammation are fundamental elements in the pathophysiology of obstructive sleep apnea. Objectives. To evaluate the effects of continuous positive airway pressure (CPAP) in reduction of atrial fibrillation after CABG in patients with obstructive sleep apnea. Methodological procedures: A multicenter randomized controlled study to compare the incidence of atrial fibrillation between the intervention group and the control group, both monitored seven days with Holter.

Enrollment: 144 patients

Sex: All

Ages: 30 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• apnea-hypopnea index > 15 events/hour

Exclusion criteria

• ejection fraction < 45%
• chronic atrial fibrillation
• periprocedural instability (haemodynamic, neurological)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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144 participants in 2 patient groups

CPAP group

Active Comparator group

Description:

patients will receive CPAP therapy for the first 7 days after extubation from CABG

Treatment:

Device: CPAP

Control Group

No Intervention group

Description:

Patients will receive usal care