Prevention of Contrast-Induced Nephropathy

University of Alberta

Status

Completed

Conditions

Chronic Renal Failure

Contrast-induced Nephropathy

Acute Renal Failure

Treatments

Drug: intravenous saline hydration + mannitol + furosemide

Drug: intravenous saline hydration

Study type

Interventional

Funder types

Other

Identifiers

NCT00175227

HSRIF #96-20

Details and patient eligibility

About

Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram.

The investigators hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls.

Full description

Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram.

We hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls.

We define an episode of contrast nephropathy using the conventional often published definition of a 25% relative increase in serum creatinine OR a 44 umol absolute increase in serum creatinine within 48 hours of contrast exposure.

Enrollment

200 estimated patients

Sex

All

Ages

21+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age > 21 years
serum creatinine > 150 umol/L
able and willing to provide informed consent

Exclusion criteria

known hypersensitivity to contrast, furosemide, or mannitol
unable to tolerate a fluid load (e.g., acute pulmonary edema)
ESRD, on dialysis
previous enrollment in this study or previous contrast administration with the last 2 weeks
refusal by treating physician