ClinicalTrials.Veeva

Menu

Prevention of Contrast-Induced Nephropathy

U

University of Alberta

Status

Completed

Conditions

Chronic Renal Failure
Contrast-induced Nephropathy
Acute Renal Failure

Treatments

Drug: intravenous saline hydration + mannitol + furosemide
Drug: intravenous saline hydration

Study type

Interventional

Funder types

Other

Identifiers

NCT00175227
HSRIF #96-20

Details and patient eligibility

About

Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram.

The investigators hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls.

Full description

Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram.

We hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls.

We define an episode of contrast nephropathy using the conventional often published definition of a 25% relative increase in serum creatinine OR a 44 umol absolute increase in serum creatinine within 48 hours of contrast exposure.

Enrollment

200 estimated patients

Sex

All

Ages

21+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • age > 21 years
  • serum creatinine > 150 umol/L
  • able and willing to provide informed consent

Exclusion criteria

  • known hypersensitivity to contrast, furosemide, or mannitol
  • unable to tolerate a fluid load (e.g., acute pulmonary edema)
  • ESRD, on dialysis
  • previous enrollment in this study or previous contrast administration with the last 2 weeks
  • refusal by treating physician

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

200 participants in 2 patient groups, including a placebo group

Intervention
Experimental group
Description:
Saline hydration + mannitol + furosemide
Treatment:
Drug: intravenous saline hydration + mannitol + furosemide
Controls
Placebo Comparator group
Description:
Saline hydration without mannitol or furosemide
Treatment:
Drug: intravenous saline hydration

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems