Prevention of Contrast Induced Nephropathy in Patients With Advanced Renal Dysfunction Undergoing Coronary Interventions

Clalit Health Services

Status: Completed

Conditions: Ischemic Heart Disease; Kidney Disease, Chronic

Treatments: Procedure: Percutaneous coronary intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT02468401

0103-15-MMC

Details and patient eligibility

About

There is a pressing need to find effective strategies for the prevention of contrast induced nephropathy in patients with advanced renal dysfunction. The current study was designed to assess the efficacy of a new protocol for preventing contrast induced nephropathy in patients with advanced renal dysfunction undergoing coronary interventions

Enrollment: 30 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients with estimated glomerular filtration rate<45ml/min undergoing coronary angiography due to one of the following indications in accordance with the 2014 guidelines:

1. Elective coronary angiography due to symptoms suggestive for angina with a positive non-invasive ischemia assessment of ≥10% of left ventricle.
2. Non ST-elevation acute coronary syndrome with a GRACE score>110

Exclusion criteria

• Patients on dialysis or those planned for dialysis in the next 3 months.
• Patients with ST-elevation myocardial infarction
• No symptoms or signs of heart failure
• Treatment with IV diuretics during the 48 hours prior to enrolment
• Patients with acute renal failure (Creatinine raise of at least 0.3mg/dl from )baseline
• Patients post coronary artery bypass surgery

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Coronary angiography

Experimental group

Description:

Patients undergoing coronary angio with or without percutaneous coronary intervention using a new protocol designed to minimize the exposure to contrast medium

Treatment:

Procedure: Percutaneous coronary intervention