Prevention of Contrast-Induced Nephropathy With Sodium Bicarbonate Bolus Injection

Osaka General Medical Center

Status and phase: Completed; Phase 4

Conditions: Emergent Coronary Procedure

Treatments: Drug: Sodium Chloride; Drug: Sodium bicarbonate

Study type: Interventional

Funder types: Other

Identifiers

NCT00700375

SBECP

Details and patient eligibility

About

This study is to investigate the effect of Sodium Bicarbonate bolus injection in patients undergoing an emergent coronary procedure for prevention of contrast-induced nephropathy.

Full description

This study is to investigate the effect of Sodium Bicarbonate bolus injection in patients undergoing an emergent coronary procedure for prevention of contrast-induced nephropathy.The End point is development of contrast-induced nephropathy.

Enrollment: 59 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing an emergent coronary procedure(within 60 minutes from admission)

Exclusion criteria

• On dialysis
• Pregnancy
• Past use of bicarbonate or N-Acetyl-Cystein in 48hr
• Past exposure to contrast media in 48hr
• Circulatory insufficiency with lactic acidosis.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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59 participants in 2 patient groups

Sodium bicarbonate

Experimental group

Treatment:

Drug: Sodium bicarbonate

Sodium chloride

Experimental group

Treatment:

Drug: Sodium Chloride