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Prevention of Hyperalgesia With Epidural Morphine

Ç

Çukurova University

Status and phase

Unknown
Phase 4

Conditions

Hyperalgesia

Treatments

Drug: Serum physiologic
Drug: Morphine

Study type

Interventional

Funder types

Other

Identifiers

NCT03225690
Hyperalgesia

Details and patient eligibility

About

American Society of Anaesthesiologist physical status (ASA) I-III 105 patients who undergoing major abdominal surgery in obstetric and gynaecology clinic were recruited to this study. Patients were randomized into the 3 groups. Lumbar epidural catheter will be inserted to the all patients. After than anaesthesia induction will provide with 2 mg/kg propofol and 0.6 mg/kg rocuronium. Desflurane and azot protoxit (N2O)-O2 will use for anaesthesia maintenance. During surgical operation, 0.3 microgram/kg/h remifentanil infusion will continuous till the end of surgery. In group I, 2 ml serum physiologic (0.9 NaCL)will apply from epidural catheter before surgical incision. In group II, 1 mg morphine will apply from epidural catheter before surgical incision. In group III, 1 mg morphine will apply from epidural catheter at the time point of peritoneum is closed. Epidural patient controlled analgesia will provide with bupivacaine for postoperative analgesia. Postoperative pain will be assessed with numerical pain scale. Postoperative analgesic requirement will be calculated. Hyperalgesia will detect with algometer and von Frey ligaments.

Full description

This randomized, double blind, controlled study will perform after obtaining informed consent and ethics approval. American Society of Anaesthesiologist physical status (ASA) I-III 105 patients who undergoing major abdominal surgery in obstetric and gynaecology clinic were recruited to this study. Patients were randomized into the 3 groups with computerized randomization programme. Lumbar epidural catheter will be inserted to the all patients. After than anaesthesia induction will provide with 2 mg/kg propofol and 0.6 mg/kg rocuronium. Desflurane and N2O-O2 will use for anaesthesia maintenance. During surgical operation, 0.3 microgram/kg/h remifentanil infusion will continuous till the end of surgery. In group I, 2 ml serum physiologic (0.9 NaCL)will apply from epidural catheter before surgical incision. In group II, 1 mg morphine will apply from epidural catheter before surgical incision. In group III, 1 mg morphine will apply from epidural catheter at the time point of peritoneum is closed. Epidural patient controlled analgesia will provide with bupivacaine for postoperative analgesia. Postoperative pain will be assessed with numerical pain scale. Postoperative analgesic requirement will be calculated. Hyperalgesia will detect with algometer and von Frey ligaments.

Enrollment

105 estimated patients

Sex

Female

Ages

20 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • ASA I-III patients
  • Patients who undergoing major abdominal surgery

Exclusion criteria

  • ASA IV and up
  • Coagulopathy

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

105 participants in 3 patient groups, including a placebo group

serum physiologic
Placebo Comparator group
Description:
2 ml serum physiologic will apply via epidural catheter before surgical incision.
Treatment:
Drug: Serum physiologic
Preemptive Morphine
Active Comparator group
Description:
1 mg morphine will apply via epidural catheter before surgical incision.
Treatment:
Drug: Morphine
Morphine
Active Comparator group
Description:
1 mg morphine will apply via epidural catheter before at the time point of the peritoneum closed.
Treatment:
Drug: Morphine

Trial contacts and locations

1

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Central trial contact

Feride Karacaer; Ebru Biricik

Data sourced from clinicaltrials.gov

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