Prevention Of Morbidity In Sickle Cell Disease Pilot Phase

Institute of Child Health

Status and phase: Unknown; Phase 2

Conditions: Sickle Cell Anaemia

Treatments: Device: auto Continuous Positive Airways Pressure (CPAP) with oxygen supplementation

Study type: Interventional

Funder types: Other

Identifiers

NCT00415727

99NR31

Details and patient eligibility

About

The hypothesis is that in sickle cell anaemia, nocturnal oxyhaemoglobin desaturation, is associated with low processing speed index, and this morbidity can be reduced with overnight auto Continuous Positive Airways Pressure and/or oxygen supplementation.

Full description

Intervention: Overnight auto Continuous Positive Airways Pressure (CPAP) with oxygen supplementation if mean overnight oxyhaemoglobin saturation is not >94% after 2 weeks of autoCPAP

Sex: All

Ages: 4 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. Age >4 years.
2. Informed consent with assent in accordance with UK ethical committee(COREC) system must be signed by the patient's parent or legally authorized guardian acknowledging written consent to join the study. When suitable, patients will be requested to give their assent to join the study.
3. Haemoglobin SS (homozygous sickle cell anaemia) diagnosed by standard techniques. Participating institutions must submit documentation of the diagnostic haemoglobin analysis.