Prevention of Mucositis in Patients With Head and Neck Cancer Treated With Radiotherapy

Chulabhorn Hospital

Status: Completed

Conditions: Radiation- Induced Mucositis; Adverse Effect of Radiation Therapy; Head and Neck Cancer

Treatments: Other: Clinacanthus nutans; Other: Normal saline with salt/Soda; Other: Boesenbergia rotunda

Study type: Interventional

Funder types: Other

Identifiers

NCT03359187

004/2559

Details and patient eligibility

About

Prevention of radiation-induced mucositis in patients with head and neck cancer treated with radiotherapy : A Double-blind Randomized Controlled Trial

Full description

To compare the effect of each herb extracts in form of mouth wash to protect or delay the onset of the radiation-induced mucositis from the adverse effects of radiation therapy in patients with head and neck cancer.

Enrollment: 120 patients

Sex: All

Ages: 15 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 15 years old or older,
• Diagnosed with Head and Neck cancer
• On treatment of external Radiation therapy

Exclusion criteria

• Pregnant
• Previously underwent external Radiation therapy
• Illiterate

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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120 participants in 3 patient groups

Normal saline with salt/Soda

Active Comparator group

Description:

Normal saline with salt/soda rinse 4 times a day/everyday and for each time 15 ml.

Treatment:

Other: Normal saline with salt/Soda

Clinacanthus nutans

Experimental group

Description:

Clinacanthus nutans in form of mouth wash rinse 4 times a day/everyday and for each time 15 ml.

Treatment:

Other: Clinacanthus nutans

Boesenbergia rotunda

Experimental group

Description:

Boesenbergia rotunda in form of mouth wash 4 times a day/everyday and for each time 15 ml.

Treatment:

Other: Boesenbergia rotunda