Prevention of Myocardial Dysfunction and Injury Resulting From Salter Innominate Osteotomy by Caudal Block

Si-Qin Chen

Status and phase: Unknown; Phase 4

Conditions: Cardiac Dysfunction; Myocardial Injury

Treatments: Drug: saline; Drug: ropivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT02144766

060717

Details and patient eligibility

About

The goal of the present study was to investigate the role of pro-inflammatory cytokines in myocardial dysfunction and injury resulting from noncardiac injury in children and whether or not anti-inflammatory treatment with caudal block prevents pro-inflammatory cytokines-associated myocardial dysfunction and injury following noncardiac surgery.

Enrollment: 40 estimated patients

Sex: All

Ages: 1 to 5 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children diagnosed for developmental dysplasia of the hip (DDH) undergoing Salter innominate osteotomy will be recruited into the study.

Exclusion criteria

• Children with anemia, electrolyte disturbances, abnormal acid-base status, bleeding diathesis, history of allergy to local anesthetics, neurologic and spinal diseases, skin infections on the caudal area, renal dysfunction, symptomatic cardiovascular and respiratory disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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40 participants in 2 patient groups, including a placebo group

Ropivacaine

Experimental group

Description:

caudal block with 1 ml/kg of ropivacaine 0.2%

Treatment:

Drug: ropivacaine

saline

Placebo Comparator group

Description:

caudal block with 1 ml/kg of saline

Treatment:

Drug: saline