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Intraoperative hypotension is a common situation. It increases postoperative morbidity and mortality, especially in patients at high postoperative risk undergoing high-risk surgery. Intraoperative hypotension is partly related to anesthesia, and mainly to the combined, dose-dependent, synergistic effect of hypnotics and opioids. Monitoring sedation and monitoring analgesia reduce intraoperative consumption of each anesthetic agent. To date, the beneficial effect of combined sedation and analgesia monitoring on the reduction of intraoperative hypotension has only been found in one study, involving major abdominal surgery. Up to now, no study has been designed to demonstrate the benefit of monitoring the two components of anesthesia on postoperative organ dysfunction and mortality.
The study propose to evaluate the relevance of a combined optimization of hypnotic and opioid agents on the most frequently encountered dysfunctions related to intraoperative hypotension.
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Inclusion and exclusion criteria
Inclusion Criteria:
patients affiliated to the French Social Security;
informed and signed consent to participating in the study;
planned postoperative hospitalization > 48 hours;
patients over 75 years of age with at least one of the following postoperative risk factors:
elective or emergency high-risk surgery under general anesthesia with a combination of hypnotic and opioid, and intubation or placement of a supraglottic airway control device:
Non inclusion criteria:
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1,132 participants in 2 patient groups, including a placebo group
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Central trial contact
David CHARIER, MD; Carine LABRUYERE, CRA
Data sourced from clinicaltrials.gov
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