Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion (PONV)

Penn State Health

Status and phase: Completed; Phase 2

Conditions: Post-operative Nausea and Vomiting

Treatments: Other: Placebo; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT05759481

STUDY00021935

Details and patient eligibility

About

The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.

Full description

Propofol is administered as both low dose and as sole anesthetic in patients with history of PONV and/or motion sickness. But efficacy of one dose over the other is not studied. This study plans to clarify if propofol in low dose is as effective as its administration as sole anesthetic in patients with history of PONV and/or motion sickness

Enrollment: 68 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Undergoing general anesthesia for elective surgery
2. Documented history of Patient's self-disclosure of PONV and/or motion sickness during pre-anesthesia discussions
3. No documented allergy/adverse reaction to propofol
4. English speaking
5. At least 18 years of age

Exclusion criteria

1. Any anti-nausea medication taken within 24 hours prior to surgery
2. Unable to provide consent independently
3. Allergy or adverse reaction to propofol
4. Emergency surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

68 participants in 2 patient groups, including a placebo group

Propofol

Experimental group

Description:

Low-dose propofol infusion at 25 mcg/kg/min

Treatment:

Drug: Propofol

Placebo

Placebo Comparator group

Description:

Same volume of 0.9% normal saline as the study group

Treatment:

Other: Placebo