Prevention of Postoperative Acute Kidney Injury (PrevenAKI)

Wuerzburg University Hospital

Status: Withdrawn

Conditions: Acute Kidney Injury

Treatments: Procedure: kidney treatment bundle (KDIGO)

Study type: Interventional

Funder types: Other

Identifiers

NCT02583945

022015

Details and patient eligibility

About

Postoperative acute kidney injury (AKI) refers to increased mortality and morbidity in patients after non-cardiac surgery. The Kidney Disease Improving Global Outcomes (KDIGO)-guidelines recommend a bundle of procedures to prevent the occurrence of AKI: A protocol for the improvement of the hemodynamic situation and a standardized proceeding in hemodynamic monitoring, consequent avoidance of nephrotoxic substances, regular measurement of creatinine and urine output, as well as normoglycemia. The primary goal is to determine if the consequent application of the KDIGO-bundle leads to a prevention of the occurrence of AKI in patients at risk after non-cardiac surgery.

Full description

All patients included in the study will be treated with the KDIGO-bundle (hemodynamic stabilization, avoidance of nephrotoxic substances, normoglycemia and measurement of creatinine in serum and urine output). 12 h, 24h as well as on day 2, 3, 5 and 10 after admission on ICU the occurence of AKI (according to KDIGO) will be assessed.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 65 years
• chronic kidney disease
• diabetes mellitus, chronic heart, lung or liver disease
• hemodynamic instability (intra and/or post-operative)
• trauma, burn injury, major surgery, usage of x-ray contrast and sepsis.

Exclusion criteria

• Age < 18 years
• pregnancy
• kidney graft recipient
• chronic renal disease with or without renal replacement therapy and cardiac surgery.

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

kidney treatment bundle (KDIGO)

Experimental group

Description:

Consequent postoperative application of a kidney treatment bundle: Protocol based hemodynamic optimization and monitoring, regular screening of creatinine in serum and of urine output, no use of potential nephrotoxic medication and normoglycemia.

Treatment:

Procedure: kidney treatment bundle (KDIGO)