Prevention of Shivering Associated With Spinal Anesthesia

Assiut University

Status and phase: Not yet enrolling; Phase 3; Phase 2

Conditions: Shivering, Spinal Anesthesia

Treatments: Drug: Meperidine; Drug: Ketamine; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT06082076

Shivering and anesthesia

Details and patient eligibility

About

The aim of the study is to compare the effectiveness of prophylactic use of intravenous (IV) dexmedetomidine VS ketamine and meperidine(as a control group) in prevention of shivering associated with intrathecal anesthesia in patients undergoing knee arthroscopy

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 20-30 Scheduled patients for knee arthroscopy under spinal anesthesia. American Society of Anesthesiologists (ASA) physical status: I and II

Exclusion criteria

• Patient refusal Aged less than 18 years or lesser than 150 cm in height Pregnant woman Allergy to the studied drugs. Patients with contraindications to spinal anesthesia. Patients with advanced decompensated cardiac, respiratory,renal or hepatic diseases, ASA III-IV Coagulopathy or thrombocytopenia CNS diseases as epilepsy, stroke or psychiatric illness.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Triple Blind

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90 participants in 3 patient groups, including a placebo group

Group D (dexmedetomidine group)

Active Comparator group

Treatment:

Drug: Dexmedetomidine

Group K (ketamine group)

Active Comparator group

Treatment:

Drug: Ketamine

Group C (control group)

Placebo Comparator group

Treatment:

Drug: Meperidine