Prevention With Oleanolic Acid of Insulin Resistance (PREOLIA)

University of Granada (UGR)

Status: Completed

Conditions: Insulin Resistance; Metabolic Syndrome

Treatments: Other: Olive oil; Other: Functional olive oil

Study type: Interventional

Funder types: Other

Identifiers

NCT05049304

B-AGR-287-UGR18

Details and patient eligibility

About

Oleanolic acid (OA), a triterpene that is highly present in olive leaves, has been proposed as component of functional foods in the prevention of metabolic syndrome due to its anti-inflammatory activity. In this research project we will study the presence of OA in postprandial TRL in healthy adolescents and in normal weight. Moreover, THP-1 macrophages will be incubated with LPS for 48h after pretreatment with OA at different concentrations. Also, TRL will be isolated from healthy adolescents before and 2 and 5h postprandially after the intake of a meal containing the functional olive oil or common olive oil and incubated with THP-1 macrophages.

Enrollment: 22 patients

Sex: All

Ages: 16 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

-Participants without digestive, metabolic or oncologic disorders or any other pathology

Exclusion criteria

-Not having the informed consent signed by the parents

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

22 participants in 2 patient groups

OA-enriched functional olive oil

Experimental group

Treatment:

Other: Functional olive oil

Olive oil not enriched in OA

Active Comparator group

Treatment:

Other: Olive oil