Preventive Application of Letrozole Decrease Incidence of Early Onset of OHSS

Sun Yat-sen University

Status and phase: Completed; Phase 4

Conditions: Ovarian Hyperstimulation Syndrome

Treatments: Drug: letrozole; Drug: Aspirin

Study type: Interventional

Funder types: Other

Identifiers

NCT02670304

28843020

Details and patient eligibility

About

Letrozole is one kind of aromatase inhibitors which may have effect on decrease estrogen in luteal phase and inhibit the luteal function of ovary. In 2009, Letrozole was reported as one candidate for the treatment or prevention of ovarian hyperstimulation syndrome.

Full description

Letrozole was proved to be effective in decreasing the estradiol level of luteal phase after ovum picked up. In this randomized controlled study, investigators try to observe the effectiveness of letrozole on decreasing the incidence of early ovarian hyperstimulation syndrome and vascular epithelium growth factor level of women with high ovarian hyperstimulation syndrome risks.

Enrollment: 100 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• infertile women undergoing IVF treatment with more than 25 oocytes collected.

Exclusion criteria

• letrozole contraindications,e.g. severe hepatic and renal dysfunction

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

letrozole

Experimental group

Description:

letrozole for the first day after ovum picked up at least for 5 days.

Treatment:

Drug: letrozole

aspirin

Active Comparator group

Description:

asprin for the first day after ovum picked up at least for 5 days.

Treatment:

Drug: Aspirin