PRF for Accelerating Palatal Healing

Çukurova University

Status: Completed

Conditions: Gingival Recession

Treatments: Other: Wet gauze; Other: Platelet Rich Fibrin; Other: Butyl cyanoacrylate

Study type: Interventional

Funder types: Other

Identifiers

NCT02712242

CukurovaU8

Details and patient eligibility

About

Backgroung: Various agents are used to reduce post-operative complications associated with palatal donor site surgery for free gingival graft (FGG) harvesting. This study was conducted to evaluate the effects of platelet-rich fibrin (PRF) on palatal wound healing.

Full description

125 patients with isolated recessions were treated. The connective tissue graft was obtained by the de-epithelialization of a free gingival graft in both groups. Three different hemostatic treatments were randomized; PRF with cyanoacrilate adhesive (PRF group, n:42), cyanoacrilate adhesive alone (BC group, n:42) and sterile wet gauze compression (WG group, n:41). Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded for different time points.

Enrollment: 125 patients

Sex: All

Ages: 21 to 48 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• no contraindications for periodontal surgery;
• full-mouth plaque score of <10%
• full-mouth bleeding score of <15%.

Exclusion criteria

• previously undergone surgery for a graft harvested from the palate
• presence of systemic disease or taking medication known to interfere with periodontal health
• smokers
• possible coagulation disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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125 participants in 3 patient groups, including a placebo group

Platelet Rich Fibrin

Experimental group

Description:

PRF was laid directly on the palatal wound immediately after harvesting the tissue graft and stabilized

Treatment:

Other: Platelet Rich Fibrin

Butyl cyanoacrylate

Active Comparator group

Description:

Butyl cyanoacrylate was directly applied on the palatal wound after harvesting the tissue graft

Treatment:

Other: Butyl cyanoacrylate

Wet Gauze

Placebo Comparator group

Description:

Wet Gauze was placed for 1 minute on the palatal wound after harvesting the tissue graft

Treatment:

Other: Wet gauze