Primary Aldosteronism In Hypertensive Patients in China (PA-China)

Qifu Li

Status: Completed

Conditions: Hypertension Secondary; Hyperaldosteronism; Primary

Treatments: Diagnostic Test: Aldosterone/renin ratio (ARR) testing; Diagnostic Test: Confirmatory tests

Study type: Observational

Funder types: Other

Identifiers

NCT03155139

PA-China 2017

Details and patient eligibility

About

To investigate the prevalence of primary aldosteronism (PA) in Chinese patients with newly diagnosed hypertension.

Full description

This is a nationwide sampling study. To investigate the prevalence of primary aldosteronism (PA) in Chinese patients with hypertension, we will conduct a case detection of PA in Chinese hypertensive patients from 10 centers of China (including Beijing, Chongqing, Shanghai, Guangzhou, et al.); furthermore, a case confirmation of PA (captopril challenge test and saline infusion test) will be performed if the result of case detection is positive. This study will be completed in two years.

Enrollment: 3,500 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Newly diagnosed hypertension(with a course less than six months);
2. Drug negative, or voluntary to discontinue/change the anti-hypertensive medications;
3. Aged between 18-80 year, gender is not limited;
4. Voluntary to sign on the informed consent.

Exclusion criteria

1. patients with severe cardiac, hepatic or renal dysfunction;
2. suspicious or confirmed other types of secondary hypertension, including Cushing's syndrome, pheochromocytoma and renal artery stenosis.

Trial design

3,500 participants in 2 patient groups

Patients without primary aldosteronism (PA)

Description:

PA case detection or confirmatory tests was negative.

Treatment:

Diagnostic Test: Aldosterone/renin ratio (ARR) testing

Patients with primary aldosteronism (PA)

Description:

PA case detection and confirmatory tests were positive.

Treatment:

Diagnostic Test: Confirmatory tests

Diagnostic Test: Aldosterone/renin ratio (ARR) testing