Primary Care Internet-Based Depression Prevention for Adolescents (CATCH-IT)

The University of Chicago

Status and phase

Withdrawn

Phase 3

Conditions

Depression

Externalizing Symptoms

Substance Abuse

Anxiety

Treatments

Behavioral: AMPE

Behavioral: CATCH-IT

Study type

Interventional

Funder types

Other

Identifiers

NCT01228890

10-464-A

Details and patient eligibility

About

In this 5-year, two-site randomized clinical trial, we propose to test the efficacy of the CATCH-IT primary care/Internet based depression prevention intervention against Attention Monitoring Psychoeducation (AMPE) in preventing the onset of depressive episodes in an intermediate to high risk group of adolescents aged 13-17. We plan to (a) identify high risk adolescents based on elevated scores on the PHQ-A, a screening measure of depressive symptoms; (b) recruit 400 (200 per site) of these at-risk adolescents to be randomized into either the CATCH-IT or the AMPE group; (c) assess outcomes at 2, 8, 12, 18, and 24 months post intake on measures of depressive symptoms, depressive diagnoses, other mental disorders, and on measures of role impairment in education, quality of life, attainment of educational milestones, and family functioning; and (d) conduct exploratory analyses to examine the effectiveness of this intervention program, moderators of protection, and potential ethnic and cultural differences in intervention response.

Sex

All

Ages

13 to 17 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Youth ages 13 through 17.
Youth must be experiencing elevated level of depressive symptoms on the Center for Epidemiologic Studies Depression46 (CES-D) scale (score >/= 16) and have at least two core symptoms of Major Depression on the Patient Health Questionnaire, Adolescents.
Youth will be included if they have a past history of depression, anxiety, externalizing symptoms, or substance abuse.

Exclusion criteria

Current DSM-IV diagnosis (Kiddie Schedule of Affective Disorders) of Major Depressive Disorder, current therapy for depression, or be taking antidepressants (e.g., SSRIs, TCAs, MAOIs, bupropion, nefazodone, mirtazapine, venlafaxine).
Current CES-D score >35
DSM-IV diagnosis of schizophrenia (current or past) or bipolar affective disorder
Current serious medical illness that causes significant disability or dysfunction
Significant reading impairment (a minimum sixth-grade reading level based on parental report), mental retardation, or developmental disabilities
Serious imminent suicidal risk (as determined by endorsement of current suicidality on CES-D or in KSADS interview) or other conditions that may require immediate psychiatric hospitalization
Psychotic features or disorders, or currently be receiving psychotropic medication
Extreme, current drug/alcohol abuse (greater than or equal to 2 on the CRAFFT).