Primary Failure of Eruption (PFE) : Highlighting of Clinical, Radiological and Genetic Diagnostic Criteria: Consequences on the Therapeutic Management

University Hospital, Strasbourg, France

Status: Enrolling

Conditions: Primary Failure of Eruption

Treatments: Genetic: genetic analysis; Radiation: panoramic radiography; Radiation: teleradiography; Radiation: intraoral X-rays; Radiation: CT scan of maxillary and mandible

Study type: Interventional

Funder types: Other

Identifiers

NCT03580785

6641

Details and patient eligibility

About

The primary purpose of the study is to identify clinical, radiological and genetic diagnostic criteria for Primary Failure of Eruption (PFE).

The secondary purposes are to highlight the genotype-phenotype correlations in the PTHR1 and non-PTHR1 forms and analyze the therapeutic failures.

Enrollment: 50 estimated patients

Sex: All

Ages: 6+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• people over 6 years old
• people with Primary Failure Eruption

Exclusion criteria

• children under 6 years old
• endocrine pathology that may interfere with dental eruption
• rickets
• chemotherapy / radiotherapy
• bisphosphonate treatment

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)