Primary Lesion Treatment for Bone Metastases

Shanghai Jiao Tong University

Status: Not yet enrolling

Conditions: Bone Metastases

Treatments: Procedure: palliative surgery; Radiation: radiotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05665790

20221202

Details and patient eligibility

About

This study will carry out a prospective cohort study to study the effect of different primary leison treatment modes on disease control, quality of life, economic cost and survival period of patients with bone metastases from breast cancer and lung cancer by giving radiotherapy or palliative surgery or not giving local treatment for the primary lesion in patients with bone metastases from breast cancer or lung cancer

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. HR positive breast cancer patients with bone metastasis or Non-small-cell lung cancer patients with bone metastasis；
2. Aged over 18;
3. ECOG：0-1；
4. Patients who benefit clinically(CR+PR) after 6 months of treatment.

Exclusion criteria

1. The expected life span is less than 3 months;
2. Have serious cardiovascular and cerebrovascular diseases, blood coagulation dysfunction, and cannot tolerate surgery;
3. Allergies to narcotic drugs;
4. The patient refused the treatment decision of the integrated team.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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400 participants in 3 patient groups

radiotherapy

Experimental group

Treatment:

Radiation: radiotherapy

palliative surgery

Experimental group

Treatment:

Procedure: palliative surgery

no primary leison treatment

No Intervention group