Primary Progressive Aphasia Multicomponent Language Treatment Study

The University of Texas System (UT)

Status: Invitation-only

Conditions: Primary Progressive Aphasia; Nonfluent Aphasia, Progressive; Semantic Dementia; Logopenic Progressive Aphasia; Aphasia, Progressive; Semantic Memory Disorder; Aphasia

Treatments: Behavioral: Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA); Behavioral: Multicomponent Communication Partner Training (Multi-CPT); Behavioral: Multicomponent Lexical Retrieval Training (Multi-LRT)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT06649084

R56DC016291 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The goal of this clinical trial is to learn if a speech-language telerehabilitation helps improve communication in people with primary progressive aphasia (PPA), a form of dementia that affects speech and language. The study will also document how acceptable and helpful the program is for both patients and their care partners.

The main questions the study aims to answer are:

1. Is the telerehabilitation program feasible and acceptable for people with PPA and their care partners?
2. Do participants with PPA and care partners report satisfaction with the program?
3. Which outcome measures are most useful for evaluating changes in communication and quality of life?
4. What patterns of treatment response are seen in participants after completing the program?

Researchers will test the program in a small group of participants to see how people respond. The program includes both speech-language therapy and training for care partners.

Participants will:

• Take part in online speech-language therapy sessions
• Complete communication tasks and questionnaires before and after the program
• Have regular virtual check-ins with the research team
• Include their care partners in some parts of the program for training and support

Enrollment: 21 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
• Scores of 10 or higher on the Mini-Mental State Examination
• Has a study partner who can consistently attend sessions

Exclusion criteria

• Other neurological or psychiatric diagnosis that may contribute to cognitive-linguistic deficits
• Significant, uncorrected visual or hearing impairment that would interfere with participation
• Score of less than 10 on the Mini-Mental State Examination
• Prominent initial non-speech-language impairment (cognitive, behavioral, motoric)

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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21 participants in 3 patient groups

Multicomponent Lexical Retrieval Training (Multi-LRT)

Experimental group

Treatment:

Behavioral: Multicomponent Lexical Retrieval Training (Multi-LRT)

Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA)

Experimental group

Treatment:

Behavioral: Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA)

Experimental: Multicomponent Communicaiton Partner Training (Multi-CPT)

Experimental group

Treatment:

Behavioral: Multicomponent Communication Partner Training (Multi-CPT)