Primary Tumor Burden Score:A Novel Staging Parameter for ESCC After nCRT

Fudan University

Status: Completed

Conditions: Neoplasm, Esophagus; Neoplasm, Squamous Cell

Treatments: Procedure: nCRT

Study type: Observational

Funder types: Other

Identifiers

NCT05839002

CMISG1708

Details and patient eligibility

About

In this case-only study, the investigators try to define a novel staging parameter, the Primary Tumor Burden Score (PTBS).

Full description

In this case-only study, the investigators try to define a novel staging parameter, the Primary Tumor Burden Score (PTBS), which will combine the proportion of residual primary tumor cells and pre-treatment pathological T stage (prepT stage). The investigators will also try to improve ypTNM stage by results of PTBS.

Enrollment: 187 patients

Sex: All

Ages: 40 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Neoadjuvant chemoradiotherapy and surgical resection of esophageal squamous cell carcinoma

Exclusion criteria

• Patients receiving neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma without surgical resection

Trial design

187 participants in 2 patient groups

Training cohort

Description:

Training cohort will be used to find the best calculation and cut-off values for PTBS in ESCC after nCRT.

Treatment:

Procedure: nCRT

Validation cohort

Description:

The study's conclusion will be verified in Zhongshan Hospital Xiamen branch.

Treatment:

Procedure: nCRT