Primed vs Unprimed Facilitatory and Depressive Paired Associative Stimulation

University of Minnesota (UMN)

Status: Completed

Conditions: Healthy

Treatments: Device: Transcranial Magnetic Stimulation (Magstim)

Study type: Interventional

Funder types: Other

Identifiers

NCT02619643

1601M82561

Details and patient eligibility

About

Following brain injury (e.g. stroke), application of non-invasive brain stimulation may improve rehabilitative efforts. However, the most effective method of non-invasive brain stimulation is unknown. Paired associative stimulation (PAS) is a method of non-invasive brain stimulation that pairs an electrical peripheral nerve stimulus with a magnetic stimulus to the head. This method can be applied in a manner that increases (facilitates) or decreases (depresses) excitability within the brain. Furthermore, applying two consecutive PAS sessions within minutes of each other (called primed PAS) may augment changes in excitability more than a single PAS session alone.

Thus, the purpose of this study is to compare the effect of a double PAS session (primed PAS) to the effect of a single PAS session (unprimed PAS) and a sham PAS session in healthy individuals.

Enrollment: 32 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ≥ 18 and ≤ 30 years of age
• Elicitable motor evoked potential from the motor cortex contralateral to the dominant hand
• Elicitable N20 sensory evoked potential

Exclusion criteria

• History of neurological disease
• Seizure within the past 2 years
• Currently taking epileptogenic medication
• Peripheral neuropathy
• Cognitive impairment and/or major psychiatric disorder
• Metal in the head (dental permitted)
• Pacemaker or other indwelling devices
• Pregnancy

Trial design

Primary purpose: Device Feasibility

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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32 participants in 7 patient groups

Primed PAS 1A

Experimental group

Description:

Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).

Treatment:

Device: Transcranial Magnetic Stimulation (Magstim)

Unprimed PAS 1B

Experimental group

Description:

A single session of active paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied.

Treatment:

Device: Transcranial Magnetic Stimulation (Magstim)

Sham PAS

Sham Comparator group

Description:

A single session of sham paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied

Treatment:

Device: Transcranial Magnetic Stimulation (Magstim)

Primed PAS 2A

Experimental group

Description:

Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).

Treatment:

Device: Transcranial Magnetic Stimulation (Magstim)

Unprimed PAS 2B

Experimental group

Description:

A single session of active paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied.

Treatment:

Device: Transcranial Magnetic Stimulation (Magstim)

Primed PAS 1C

Experimental group

Description:

Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).

Treatment:

Device: Transcranial Magnetic Stimulation (Magstim)

Primed PAS 2C

Experimental group

Description:

Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).

Treatment:

Device: Transcranial Magnetic Stimulation (Magstim)