Prize Contingency Management for Cocaine-Dependent Methadone Patients

UConn Health

Status: Completed

Conditions: Cocaine Abuse

Treatments: Behavioral: prize contingency management

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01401270

10-256-2

R01DA013444 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The investigators will randomize 300 cocaine-dependent methadone patients to 1 of 6 conditions: (a) a control group, (b) a contingency management condition that arranges a 100% probability of winning a prize with each draw and has 3 prize categories, (c) a contingency management condition that arranges a 31% probability of winning and has 3 prize categories, (d) a contingency management condition that arranges a 100% probability of winning and has 7 prize categories, (e) a contingency management condition that arranges a 31% probability of winning and has 7 prize categories, or (f) usual prize contingency management with a 50% probability of winning from 3 prize categories. Magnitudes of reinforcement will be identical across conditions, but lower overall probability conditions arrange for greater chances of winning larger magnitude prizes. The investigators expect that the new contingency management conditions will reduce cocaine use relative to the control condition, that 31% probability conditions will decrease drug use relative to 100% conditions, and that 7-prize category conditions will reduce drug use compared to 3-prize category conditions. In addition, the 31%/7-category condition is expected to be most efficacious. Results will be instrumental for further developing prize contingency management to improve outcomes of cocaine-dependent methadone patients.

Enrollment: 280 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age > 18 years
• current DSM-IV diagnosis of cocaine dependence
• enrolled at the clinic for >3 months
• on a stable dose of methadone (no changes) for >1 month and not requesting a dose alteration
• submitted >1 clinic cocaine positive sample in the last 6 months
• English speaking
• pass a quiz related to understanding the informed consent form

Exclusion criteria

• serious, uncontrolled psychiatric illness
• significant cognitive impairment
• in recovery from pathological gambling

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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280 participants in 6 patient groups

Treatment Group A

No Intervention group

Description:

Standard Care

Treatment Group B

Experimental group

Description:

100% probability of winning a prize with each draw and has 3 prize categories

Treatment:

Behavioral: prize contingency management

Treatment Group C

Experimental group

Description:

31% probability of winning and has 3 prize categories

Treatment:

Behavioral: prize contingency management

Treatment Group D

Experimental group

Description:

100% probability of winning and has 7 prize categories

Treatment:

Behavioral: prize contingency management

Treatment Group E

Experimental group

Description:

31% probability of winning and has 7 prize categories

Treatment:

Behavioral: prize contingency management

Treatment Group F

Experimental group

Description:

usual prize contingency management with a 50% probability of winning from 3 prize categories

Treatment:

Behavioral: prize contingency management