Pro-inflammatory Cytokines in Blood From Orthopedic Surgery Compared to Abdominal Aneurysm Repair (KEEP-HB)

Sykehuset i Vestfold HF

Status

Unknown

Conditions

Osteoarthritis, Hip

Aortic Diseases

Treatments

Device: Sangvia blood sampling system

Study type

Observational

Funder types

Other

Industry

Identifiers

NCT00851149

6.2009.36

Details and patient eligibility

About

The purpose of this study is to investigate the contents in blood sampled from surgery site during hip replacement compared with blood sampled from abdominal aortic surgery. Is there any difference in pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-α), complement activation (C3a)?

Full description

Patient (n= 10) scheduled for total hip replacement or hemiprosthesis and patient (n=10) scheduled for abdominal aortic surgery.

Primary outcome:

Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups.

Secondary outcome:

Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups.

Enrollment

20 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

ASA 1-4

Exclusion criteria

Patient using corticosteroids, NSAIDs or Cox-II inhibitors
Patients under 18 years
Patients who are included in pharmaceutical studies
Opioids-, benzodiazepines-, antiepileptic drugs-, alcohol- and α2-agonists abuse
Pregnant and breastfeeding women
Patients with known hypersensitivity for opioids, propofol or volatile anesthetics
Patients with serious arrhythmias (atrial fibrillation/flutter is acceptable)
Uncontrolled hypertension, serious psychiatric disease
Patients with unstable angina pectoris or myocardial infarction the last month before inclusion
Acute abdominal aortic surgery (acute dissection or rupture)
Planned laparoscopic abdominal aortic aneurysm surgery
Transfusion of blood products last month before surgery
Glucocorticoid users