Probing Neural Circuitry for the Control of Movement

University of Zurich (UZH)

Status: Completed

Conditions: Neurological Movement Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT02150642

EK-11/2004 / PB_2016-00229

Details and patient eligibility

About

The investigators are interested in examining 1) the basic organization of spinal and cortical circuitry for the control of movement and 2) the influence of injury of these circuits. To investigate the neuronal circuitry, the investigators use various types of mechanical or electrical stimulation of the limbs, transcranial magnetic stimulation of the cortex and galvanic vestibular stimulation in both uninjured human subjects and subjects with a neurological injury (such as spinal cord injury, or Parkinsons's disease).

Enrollment: 250 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• control subjects: no neurological movement disorder
• patients: neurological movement disorder

Exclusion criteria

patients and control subjects:

• presence of any central psychiatric disorder that precludes subject from giving informed and voluntary consent
• presence of any cardiovascular conditions or limitations that restrict the ability to walk on a treadmill continuously for more than 20 minutes
• for the electrical stimulation examination, subjects with metal implants are also excluded
• for the TMS and GVS examination, subjects with the following conditions are excluded: metal implants in the head, cardiac pacemakers, history of migraine headaches, history of major head injury, history of stroke, history of seizures, previous brain neurosurgery, unstable medical conditions, major psychiatric disorders, pregnancy -

Trial design

250 participants in 2 patient groups

Neurological Injury

No Neurological Injury