Probiotic Administartion to Mothers of Preterm Infants to Prevent Necrotizing Enterocolitis and Sepsis

Tel Aviv Sourasky Medical Center

Status: Terminated

Conditions: Necrotizing Enterocolitis; Sepsis

Treatments: Drug: Probiotics

Study type: Interventional

Funder types: Other

Identifiers

NCT00835874

TASMC-06-SD-363-CTIL

Details and patient eligibility

About

We hypothesize that supplementing maternal diet with probiotics will decrease the incidence of feeding intolerance, necrotizing enterocolitis and sepsis in preterm infants fed breastmilk.

Full description

Oral probiotics have previously been shown to prevent necrotizing enterocolitis in preterm infants. A few reports of sepsis by a probiotic bacteria have impeded implementation of oral probiotic supplementation in most NICUs. Considering the proven immunomodulatory effect of maternal probiotics on breastfed infants of atopic mothers, we would like to explore the indirect effects of maternal probiotics on preterm infants

Enrollment: 57 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mothers of preterm infants
• Pumping breast milk

Exclusion criteria

• Neonatal congenital anomalies

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind