Probiotic on Psychological and Cognitive Effects

Kent State University

Status

Completed

Conditions

Aging

Treatments

Other: Placebo

Dietary Supplement: Probiotic - Lactobacillus Rhamnosus GG

Study type

Interventional

Funder types

Other

Identifiers

NCT03080818

Kent State University

Details and patient eligibility

About

This study will determine whether supplementation of probiotic Lactobacillus Rhamnosus GG improves psychological status in middle age and older adults through a 12-week, randomized, double-blind, placebo-controlled clinical trial. Secondary analyses will be conducted to examine the possible benefits of probiotic supplementation on cognitive function and markers of physical health.

Enrollment

200 patients

Sex

All

Ages

55 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 55-75 years
Able to speak and read English

Exclusion criteria

History of neurological, developmental, or severe psychiatric disorder (e.g. dementia, stroke, schizophrenia);
Antibiotic use in the past 30 days;
History of significant stomach or GI surgery (e.g. gastric bypass, cholecystectomy);
History of alcohol or illicit drug dependence;
History of severe heart, kidney, or liver problems (e.g. heart failure, liver failure);
Regular use of an acid-blocking medication in the past 30 days (i.e. proton pump inhibitor, H2 blocker);
Likely immunosuppression (e.g. chemotherapy treatment);
Regular use of other pre- or probiotic supplements in the past 30 days;
Severe gastrointestinal conditions including celiac disease, Crohn's disease, or diverticulitis.