Probiotic Yoghurt Effect on Experimental Gingivitis

Marmara University

Status and phase: Completed; Early Phase 1

Conditions: Gingivitis

Treatments: Dietary Supplement: Natural Yoghurt; Dietary Supplement: Probiotic Yoghurt

Study type: Interventional

Funder types: Other

Identifiers

NCT02546206

MAR-2011-10-11/14

Details and patient eligibility

About

The aim of this study was to evaluate the effects of probiotic yoghurt on the development of gingival inflammation.

Fifty-one periodontally healthy individuals were given standard oral hygiene instructions and randomly divided into two groups. The test group subjects (n=26) consumed probiotic yoghurt containing Bifidobacterium animalis subsp. lactis and the control subjects (n=25) natural yoghurt for 28 days. Following yoghurt consumption, mechanical plaque control was interrupted for the next 5 days in both groups. Gingival crevicular fluid (GCF) samples and clinical data (consisted of plaque and gingival indices, probing depth, bleeding on probing) were collected at baseline, after 28 and 33 days. Interleukin-1β levels were determined in GCF by ELISA.

Full description

Probiotics are viable bacteria with scientifically confirmed health benefits for gastrointestinal system. However, there is paucity of information on its impact in periodontal disease. The aim of this study was to evaluate the effects of probiotic yoghurt on the development of gingival inflammation.

Fifty-one periodontally healthy individuals were given standard oral hygiene instructions and randomly divided into two groups. The test group subjects (n=26) consumed probiotic yoghurt containing Bifidobacterium animalis subsp. lactis and the control subjects (n=25) natural yoghurt for 28 days. Following yoghurt consumption, mechanical plaque control was interrupted for the next 5 days in both groups. Gingival crevicular fluid (GCF) samples and clinical data (consisted of plaque and gingival indices, probing depth, bleeding on probing) were collected at baseline, after 28 and 33 days. Interleukin-1β levels were determined in GCF by ELISA.

Enrollment: 51 patients

Sex: All

Ages: 16 to 26 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• No or minimal clinical signs of gingival inflammation
• Gingival Index ≤ 1
• No probing depth (Probing depth > 3 mm)
• No approximal attachment loss > 2 mm
• Non smokers

Exclusion criteria

• Systemic diseases
• Antibiotics and anti-inflammatory drugs within 3 months before the study
• Untreated caries lesions or local retention factors
• Mouth-breathing
• Allergies
• Previous probiotic supplements in diet

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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51 participants in 2 patient groups, including a placebo group

Probiotic Yoghurt

Experimental group

Description:

Probiotic yoghurt consumption

Treatment:

Dietary Supplement: Probiotic Yoghurt

Natural Yoghurt

Placebo Comparator group

Description:

Natural yoghurt consumption

Treatment:

Dietary Supplement: Natural Yoghurt