Probiotics Against Pathogenic Bacteria in Connection With Anaesthesia

Region Skane

Status: Completed

Conditions: Oropharyngeal Microbiology

Treatments: Dietary Supplement: Probiotics

Study type: Interventional

Funder types: Other

Identifiers

NCT01521650

ProAnest

Details and patient eligibility

About

Longer surgical procedures require intubation and there is a potential risk of contaminating the lower airways with pathogenic bacteria from the mouth and oropharynx.

Healthy people seldom have pathogenic bacteria originating from the gastro-intestinal canal but those do occur among patients, both in those not so sick and patients with more severe problems.

For ICU patients we have seen a reduction of emerging enteric bacteria in patients given oral care with probiotics and this is a pilot study to explore the possibility of the same kind of positive effects in patients due for longer (more than 4 hours of anesthesia) procedures.

Randomisation

• No prophylaxis
• Preparation with a probiotic suspension before intubation.

Cultures

• oropharynx

  • before treatment
  • after intubation
  • before extubation
  • day 1 postoperatively

• tracheal secretions

  • after intubation
  • before extubation

Enrollment: 42 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients
• Planned interventions
• Anaesthesia > 4 hours and requiring intubation

Exclusion criteria

• Ulcers in the mouth, oropharynx, oesophagus and stomach
• Current infections in the airways
• Known immuno deficiences
• Emergency cases

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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42 participants in 2 patient groups

Probiotics

Experimental group

Description:

Patients will gurgle and swallow a mixture of probiotic bacteria

Treatment:

Dietary Supplement: Probiotics

Control

No Intervention group

Description:

No intervention. What has been the standard procedure so far