Probiotics Effects to Initial Periodontal Treatment

Marmara University

Status: Completed

Conditions: Chronic Periodontitis

Treatments: Procedure: SRP; Dietary Supplement: probiotic or natural yoghurt

Study type: Interventional

Funder types: Other

Identifiers

NCT05408364

MAR-2011-03-30-24

Details and patient eligibility

About

The aim of this study is to evaluate the clinical and microbiological effects of Bifidobacterium animalis subsp. lactis DN-173010 containing yoghurt as an adjunct to mechanical periodontal treatment.

Full description

The aim of this study is to evaluate the clinical and microbiological effects of Bifidobacterium animalis subsp. lactis DN-173010 containing yoghurt as an adjunct to mechanical periodontal treatment.

Thirty chronic periodontitis patients were randomized into 2 groups. As adjunctive to MPT, Group 1 consumed 2×108 CFU/day of Bifidobacterium animalis subsp. lactis DN-173010 containing probiotic yoghurt while Group 2 natural yoghurt once daily for 28 days. Subgingival plaque samples were obtained from 2 periodontal sites with probing pocket depth (PPD) of 4≤PPD<7 mm via paper-points at baseline, 28th day, 3rd month. Samples were cultured to evaluate total viable count (TVC), the proportions of obligate anaerobes (OA) and Bifidobacterium species (B) (TVC%). The full-mouth recorded clinical parameters were plaque index, gingival index, PPD, bleeding on probing, and clinical attachment level.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• chronic periodontitis patients with radiographically detected horizontal bone loss
• the presence of at least 2 teeth with one approximal site with a probing pocket depth (PPD) of 4≤SD<7 mm (5-7 mm) and a GI of ≥2 mm in each quadrant,
• previously untreated periodontitis, systemically healthy

Exclusion criteria

• Systemic diseases
• Antibiotics and anti-inflammatory drugs within 3 months before the study
• Untreated caries lesions or local retention factors
• Allergic reactions to lactose or fermented milk products
• Previous probiotic supplements in diet
• Smoking
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

Natural yoghurt

Placebo Comparator group

Description:

SRP+nature yogurt (Danone® yogurt, Luleburgaz, Türkiye)

Treatment:

Dietary Supplement: probiotic or natural yoghurt

Procedure: SRP

Probiotic yoghurt

Experimental group

Description:

SRP+probiotic containing yogurt (Danone Activia® Plain, Luleburgaz, Türkiye)

Treatment:

Dietary Supplement: probiotic or natural yoghurt

Procedure: SRP