Probiotics for Irritable Bowel Syndrome

Norwegian University of Science and Technology

Status: Completed

Conditions: Irritable Bowel Syndrome; Functional Gastrointestinal Disorders

Treatments: Dietary Supplement: placebo followed by Lactobacillus plantarum MF 1298; Dietary Supplement: Lactobacillus plantarum MF1298 followed by placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT00355810

REK 4.2005.2284

Details and patient eligibility

About

This randomised, double blind, cross-over study compares the effect (symptoms, fecal bacterial growth, gas production) of three weeks' treatment with lactobacillus plantarum MF 1298 with placebo in patients with irritable bowel syndrome. The results are related to dietary habits, food intolerance and food allergy.

Enrollment: 19 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Irritable bowel syndrome according to the Rome II criteria
• regular symptoms

Exclusion criteria

• Use of probiotics last three weeks
• pregnancy
• lactation
• co-existing other gastrointestinal disorders
• use of laxatives and antibiotics within last 5 weeks.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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19 participants in 2 patient groups

placebo followed by probiotic

Experimental group

Description:

placebo, then washout period, then Lactobacillus plantarum MF1298

Treatment:

Dietary Supplement: placebo followed by Lactobacillus plantarum MF 1298

probiotic followed by placebo

Experimental group

Description:

Lactobacillus plantarum MF1298, then washout period, then placebo

Treatment:

Dietary Supplement: Lactobacillus plantarum MF1298 followed by placebo