Probiotics on Immune Function and Intestinal Microbiota in Astronauts Under Closed Microgravity Environment

Yakult

Status

Completed

Conditions

Immune Function and Intestinal Microbiota

Treatments

Dietary Supplement: Probiotic capsule

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT02618005

Probiotics

Details and patient eligibility

About

Human immune function and intestinal microbiota are suggested to be altered within long-duration stay in space. Accumulated evidences on earth support that Lacticaseibacillus paracasei strain Shirota (LcS) is a promising probiotic strain on improvement of immune function and intestinal microbiota. This study aims to investigate the impact of long-duration spaceflight as well as intake of LcS on the international space station (ISS), on immune system and intestinal microbiota in astronauts.

Enrollment

10 patients

Sex

All

Ages

25 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Individuals who are scheduled to stay on the ISS for at least 3 months
Individuals who fully understand the study protocol and provide written informed consent for the study participation

Exclusion criteria

Individuals who routinely use antibiotic, laxative, and/or bowel regulating medicine
Individuals who participate in other research that competes with this study in terms of the purpose and field, e.g., study with dietary management or intake of bifidobacteria/lactic acid bacteria, oligosaccharides, antibiotic, laxative, and/or bowel regulating medicine