Problems With Immune Recovery in the Gut Tissue

University of Minnesota (UMN)

Status: Completed

Conditions: Human Immunodeficiency Virus

Treatments: Procedure: Genital and rectal swabbing

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01460433

0712M22449

P01AI074340 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The aim of this study is to find out if the process of HIV replication in the lymph tissue and gut tissue of people taking HIV drugs causes long-term damage to the ability of the gut to protect you from other infections and health problems.

Enrollment: 21 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

HIV+ individuals

• Seropositive for HIV
• On ART for at least 12 months
• Seropositive for Herpes Simplex Type 2 and Cytomegalovirus
• Age ≥ 18 years
• Negative pregnancy test for eligible women of childbearing potential

HIV- individuals

• Seronegative for HIV
• Seropositive for Herpes Simplex Type 2 and Cytomegalovirus
• Age ≥ 18 years
• Negative pregnancy test for eligible women of childbearing potential

Exclusion criteria

• Taking daily suppressive therapy for Herpes Simplex Type 2
• Contraindication to surgical & endoscopic procedures (as judged by PI)
• Psychiatric or psychological illness that would make adherence to protocol procedures unlikely
• Pregnancy