Procalcitonin and Threatened Premature Delivery (MAPPRO)

Centre Hospitalier Departemental Vendee

Status: Terminated

Conditions: Premature Delivery; Pregnancy

Treatments: Other: procalcitonin

Study type: Interventional

Funder types: Other

Identifiers

NCT01977079

CHD061-13

Details and patient eligibility

About

Among all patients hospitalized for Threatened Premature Delivery (TPD), the rate of premature birth (PB) before 37 weeks is about 42%, which reflects the inability to accurately identify patients at high risk of PB. Currently, no clinical or biological marker is recognized as the most reliable in predicting the real risk of AP in case of MAP.

The purpose of this study is to improve the knowledge of predictors of preterm delivery compared with conventional blood markers by estimating serum procalcitonin according to premature delivery or not in patients hospitalized for preterm labor .

Enrollment: 131 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age > 18 year
• Ongoing pregnancy with a start date of pregnancy known and confirmed by an ultrasound of the 1st Quarter performed between 10 and 14 weeks with a measurement of the crown-rump length
• hospitalization for preterm labor between 24 and 36 weeks of gestation
• Intact membranes,
• not opposed to participate in the study

Exclusion criteria

• Pregnancy uncertain term (no early ultrasound)
• Pregnancy combining a condition that can interfere with the assays performed,
• Uterine malformation known
• Multiple pregnancy,
• Premature rupture of membranes,
• Chrorio-amnionitis,
• Fetal malformation known
• Strapping
• GB> 15000 and CRP> 10 mg / L,
• No affiliation to a social security scheme.
• Woman with a measure of legal protection

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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131 participants in 2 patient groups

Premature birth

Other group

Description:

At the end of the study patients will be divided into two groups: "Premature delivery" versus "No premature delivery." Prematurity is defined as a birth before 37. In each group, the procalcitonin rate be estimated with a confidence interval of 95% and compared from a logistic regression.

Treatment:

Other: procalcitonin

Not premature birth

Other group

Description:

At the end of the study patients will be divided into two groups: "Premature delivery" versus "No premature delivery." Prematurity is defined as a birth before 37. In each group, the procalcitonin rate be estimated with a confidence interval of 95% and compared from a logistic regression.

Treatment:

Other: procalcitonin