Procalcitonin as a Marker for the Length of Antibiotic Treatment in Peritonitis and Intra-abdominal Infections

Lausanne University Hospital (CHUV)

Status: Completed

Conditions: Secondary or Tertiary Peritonitis

Study type: Observational

Funder types: Other

Identifiers

NCT01155739

141/08, Propéritonite

Details and patient eligibility

About

Procalcitonin level used for determining length of antibiotic treatment in peritonitis and intra-abdominal infections. Hypothesis is that length of antibiotic use can be shortened by this method.

Full description

Prospective randomized trial

Enrollment: 162 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• More than 18 yo
• Patient requiring surgery for peritonitis or intra-abdominal infection following: perforation, necrosis, previous operation...
• Mannheim Peritonitis score > 14
• SIRS present
• Probability of survival > 72h
• Informed consent by patient/relatives

Exclusion criteria

• No SIRS
• Long date corticoid treatment
• Immunosuppression
• Thyroid medullary carcinoma
• Anaphylactic shock
• Acute hepatic deficiency

Trial design

162 participants in 2 patient groups

procalcitonine monitoring

Description:

PCT group: antibiotic use is tailored by serum procalcitonin values, determined every 48houres.

control group

Description:

control group: antibiotic use and length of treatment as defined by guidelines