Procalcitonin Protocol Use to Guide Antibiotic Therapy Duration in the Intensive Care Unit

Methodist Health System

Status: Invitation-only

Conditions: Comparing Antibiotic Duration of Therapy

Treatments: Other: compare antibiotic duration of therapy

Study type: Observational

Funder types: Other

Identifiers

NCT05756049

117.PHA.2022.R

Details and patient eligibility

About

To compare and contrast antibiotic use and its effects on patient outcomes before and after the implementation of a PCT protocol in the ICU at Methodist Richardson Medical Center (MRMC).

Full description

Based on previous clinical trials, current literature supports the use of PCT levels in combination with clinical assessments to help determine optimal antibiotic therapy. On May 30, 2022, MRMC launched a PCT protocol in the ICU that allows clinical pharmacy specialists to order PCT levels in certain bacterial infections. In order to determine the effects of the protocol, a retrospective quasi-experimental review will be conducted

Enrollment: 208 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ● Patients aged 18 years or older

  • Patients being monitored on the PCT protocol

  • ICU location status for at least part of the admission

  • Received antibiotics in the ICU for a diagnosis of:

    • Community-acquired pneumonia
    • Hospital-acquired pneumonia
    • Ventilator-associated pneumonia
    • Sepsis and/or septic shock
    • Uncomplicated bacteremia with known source
    • Chronic obstructive pulmonary disorder exacerbation
    • Asthma exacerbation

Exclusion criteria

• Received antibiotics in the ICU for a diagnosis of:

  • Uncomplicated skin and soft tissue infections

  • Abscess

  • Empyema

  • Bacterial infections that require prolonged antibiotic therapy (e.g., osteomyelitis, endocarditis, tuberculosis, etc.)

  • Intra-abdominal infection

  • Urinary tract infection

  • Bacterial meningitis

    • Estimated Glomerular Filtration Rate <15 mL/min
    • Requiring renal replacement therapy
    • Status post cardiac arrest/target temperature management