Procedural Sedation in Renal Sympathetic Denervation

Ebru Girgin Dinc

Status: Completed

Conditions: Conscious Sedation; Dexmedetomidine; Procedural Sedation and Analgesia; Sympathectomy; Hypertension, Resistant

Study type: Observational

Funder types: Other

Identifiers

NCT07293273

RSD-S01

Details and patient eligibility

About

This retrospective, single-center study investigates the effects of two different sedation regimens-dexmedetomidine versus fentanyl-propofol-on clinical outcomes in patients undergoing catheter-based renal sympathetic denervation for resistant hypertension. The study focuses on peri-procedural safety, recovery, and overall tolerability of sedation approaches in this interventional setting.

Full description

Renal sympathetic denervation has emerged as a therapeutic option for patients with resistant hypertension, yet optimal sedation practices remain unclear. Sedation during catheter-based procedures requires a balance between patient comfort, hemodynamic stability, and minimization of respiratory complications. Dexmedetomidine offers sedative and analgesic effects with minimal respiratory depression, whereas fentanyl-propofol provides rapid, effective sedation but may increase the risk of hemodynamic and respiratory instability. This study retrospectively compares the two strategies by examining intraoperative physiological parameters, complication profiles, and post-procedural recovery measures, aiming to generate evidence that can support anesthesiologists in selecting safer and more effective sedation protocols for this high-risk patient population.

Enrollment: 142 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-80 years
• Underwent renal sympathetic denervation for resistant essential hypertension (2023-2024)
• Both male and female

Exclusion criteria

• Age <18
• Pregnant women

Trial design

142 participants in 1 patient group

Renal Sympathetic Denervation Patients (Retrospective Cohort)

Description:

All patients who underwent renal sympathetic denervation for resistant hypertension will be retrospectively included. Within this cohort, patients will be categorized into two subgroups according to sedation regimen: Group D: Dexmedetomidine sedation Group P: Fentanyl + Propofol sedation Comparative analysis will assess peri- and post-procedural safety, hemodynamic stability, and recovery outcomes.