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Processing and Effects of Cannabis

U

UMC Utrecht

Status and phase

Unknown
Phase 1

Conditions

Hypotension
Tachycardia

Treatments

Drug: Smoking of cannabis cigarettes (different strength)

Study type

Interventional

Funder types

Other

Identifiers

NCT00225407
V/267002

Details and patient eligibility

About

The purpose of this study is to investigate the processing of cannabis, and to investigate the occurrence of effects of cannabis on the cardiovascular system and the central nervous system; at higher levels of exposure.

Full description

In Europe, cannabis is the most illicit used drug, mainly for its psychoactive properties (becoming "high" or "stoned"). The active compound in cannabis is THC (tetrahydrocannabinol). In recent years the strength of cannabis (marihuana) available on the market in the Netherland has increased (especially "netherweed"). The THC-content has increased from on average 8.6% in 2000 to on average 20.3% in 2004. Experienced users adapt their habit of smoking to the strength of the cannabis sigaret (joint). However, there is also a group of people, mainly young ones, who intent to smoke the joint entirely, and can therefore be exposed to higher levels of THC. Information is lacking about the effects of cannabis at higher levels of exposure. Because of this, the Ministry of Health, Welfare, and Sports of the Netherlands ordered the investigators to perform a study to gain more insight in this issue.

Sex

Male

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Cannabis users (2-9 joints per month)

Exclusion criteria

  • Psychiatric illness
  • Evidence of excessive alcohol abuse
  • Use of other drugs

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

Trial contacts and locations

1

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Central trial contact

Tjeert T Mensinga, MD, PhD

Data sourced from clinicaltrials.gov

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