PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2)

Indiana University

Status: Completed

Conditions: Parkinson Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01536821

1105005340

Details and patient eligibility

About

The PROGENI Family Study is part of a larger consortium that is studying a gene shown to be important in Parkinson's disease, called LRRK2. People who have a defect in the LRRK2 gene will often develop Parkinson's disease. Eligible participants will be asked to complete a single Study Visit at an affiliated research facility closest to their home.

Full description

Participants will be asked to complete a family history questionnaire, which will gather information about their family history of Parkinson's disease and related disorders. They will be asked to complete a single Study Visit, during which they will be asked to do some or all of the following:

1. Complete questionnaires regarding Parkinson's disease symptoms, medical history, mood, sleep, mental status, and activity level.
2. Be given a brief standard neurological examination.
3. Be given a scratch and sniff smell identification test.
4. Be asked to give a sample of approximately 2 tablespoons of blood.
5. Be asked to give a urine sample of approximately 1 tablespoon of urine.

Enrollment: 81 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Positive for a LRRK2 mutation