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Progesterone Induced Blocking Factor Expression Levels in Endometrial Cancer Cells.

K

Kayseri Education and Research Hospital

Status

Completed

Conditions

Progesterone Induced Blocking Factor in Endometrial Cancer

Study type

Observational

Funder types

Other

Identifiers

NCT02852954
2016/405

Details and patient eligibility

About

Immune system suppression effect of Progesterone Induced Blocking Factor(PIBF), it could be questionable whether tumor cells express PIBF for escape of immune system. There are some studies in the literature that evaluate PIBF expression of different malign cells (e.g. glioblastoma multiforme as a malign central nerve system, leukemia, astrocytoma as a primary brain tumor, lung cancer and chorionic carcinoma). According to previous studies PIBF has been used as an anti-tumor immune suppressor by tumor cells. There is no data about the PIBF expression of endometrial tumor cells. Therefore, the investigators aim to determine the PIBF expression levels in the endometrial cancer cells.

Full description

This retrospective controlled study will be conducted at both Obstetrics and Gynecology clinics and Pathology clinics of Kayseri Training and Research Hospital. This study will be conducted with the use of formalin fixed paraffin embedded tissue blocks immunohistochemically to determine the PIBF expression levels in the samples. There are three groups in this study; endometrial cancer, endometrial hyperplasia and normal endometrium and each of the groups contained 20 paraffin embedded blocks provided form the Pathology clinic of Kayseri Training and Research Hospital archives.

Enrollment

60 patients

Sex

Female

Ages

20 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • diagnosed endometrial cancer
  • diagnosed endometrial hyperplasia

Exclusion criteria

  • diagnosed cancer except endometrial cancer

Trial design

60 participants in 3 patient groups

study group1
Description:
20 paraffin embedded blocks which was diagnosed endometrial cancer
control group
Description:
20 paraffin embedded blocks of healthy women
study group2
Description:
20 paraffin embedded blocks which was diagnosed endometrial hyperplasia

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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