Progesterone Levels and Endometrial Compaction in Frozen-Thawed Embryo Transfer Cycles

C

Cem Demirel

Status

Unknown

Conditions

Implantation; Placenta
Infertility of Uterine Origin
Infertility, Female

Treatments

Diagnostic Test: transvaginal ultrasound,

Study type

Observational

Funder types

Other

Identifiers

NCT04554654
9995381

Details and patient eligibility

About

This study is intended to determine whether there is a correlation between endometrial compaction and serum progesterone levels on the day of frozen embryo transfers by using transvaginal sonography for the endometrial assessment.

Full description

This study is planned to be conducted by prospectively evaluating approximately 200 frozen embryo transfers within 6 months in a single center. Patients planned to be included in the study are started estrodiol 6 mg / day on day2-3 of mensturation. 12 days after the start of estrogen, patients who have endometrial thickness over 7 mm are then started vaginal progesterone supplementation as per routine practice and are eventually proceeded to embryo transfer either on day 4 or 6 of progesterone supplementation. In this study investigators are intended to measure endometrial thickness transvaginally on the day of embryo transfer to accurately determine the presence of endometrial compaction, assess serum progesterone levels, evaluate any possible correlations between endometrial compaction, serum progesterone levels and pregnancy rates.

Enrollment

200 estimated patients

Sex

Female

Ages

20 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Woman aged 20-40 years
  • Hormonal(estrogen and progesterone) frozen- thawed embryo transfer cycles
  • Having available blastocyst(s) cryopreserved by vitrification method.

Exclusion criteria

  • Recurrent implantation failure
  • Recurrent pregnancy loss
  • Presence of uterine pathology
  • Requirement for fresh embryo(s);
  • Presence of any clinically relevant systemic disease contraindicated for assisted reproduction or pregnancy
  • Allergy history for relevant drugs
  • Body mass index of <18 or >38 kg/m2 at screening
  • Current breastfeeding or pregnancy
  • Refusal or inability to comply with the requirements of the protocol for any reason, including scheduled clinic visits and laboratory tests
  • Natural or modified natural cycles

Trial design

200 participants in 1 patient group

frozen embryo transfer cycles
Description:
patients undergoing frozen embryo transfer with artificial hormone replacement
Treatment:
Diagnostic Test: transvaginal ultrasound,

Trial contacts and locations

0

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Central trial contact

Cem Demirel, MD

Data sourced from clinicaltrials.gov

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