Progesterone Rise in Agonist Versus Antagonist in Vitro Fertilization (IVF) Cycles

Universitair Ziekenhuis Brussel

Status and phase: Unknown; Phase 4

Conditions: Pregnancy Outcome After In Vitro Fertilization (IVF)

Treatments: Other: In vitro fertilization

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01191710

ProgRise001

Details and patient eligibility

About

The aim is to explore whether the incidence of progesterone rise in the late follicular phase differs between GnRH-agonist and GnRH-antagonist protocols for IVF and whether this has an impact on the probability of pregnancy achievement.

Full description

In view of the current debate concerning possible differences in efficacy between the two GnRH analogues, the current study aimed to explore whether progesterone control in the late follicular phase differs when GnRH-agonist is used as compared to GnRH-antagonist and if so to what extend does the progesterone rise have an impact on the probability of achieving a pregnancy.

Enrollment: 200 patients

Sex: Female

Ages: 21 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age < 39
• follicle-stimulating hormone (FSH) < 12
• gonadotropin dose 100-300IU

Exclusion criteria

• endometriosis
• known endocrine disorder
• blood analyzed in another laboratory

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

Antagonist group

Experimental group

Description:

Antagonist protocol for IVF

Treatment:

Other: In vitro fertilization

Agonist group

Active Comparator group

Description:

Long Agonist protocol for IVF

Treatment:

Other: In vitro fertilization